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I. Synthesis of labeled compounds

Customised isotopic labeling (made to order) with 2H, 13C, and 15N of special organic compounds, i.e. compounds not offered by traditional manufacturers.
Expert advice to the user on the identification of optimal isotopic labeling schemes and analytical techniques used for the final product analysis (Mass Spectrometry and/or NMR Spectroscopy).
Marked Compounds Portfolio:

No.Compounds marked with D, 13C and 15N FormulaAtom %
1Nitric acid-15N, solution199
2Sodium nitrate-15N299
3Potassium nitrate-15N
3
99
4Calcium nitrate-15N2
4
99
5Ammonium nitrate-15N
5
99
6Ammonia-15N
6
99
7Ammonium chloride-15N
7
99
815N-ammonium nitrate
8
99
9Ammonium nitrate-15N2
9
99
10Ammonium sulfate-15N2
10
99
11Diammonium hydrogen phosphate-15N2
11
99
12Sodium nitrite-15N
12
99
13Potassium nitrite-15N
13
99
14Nitrogen-15N2
14
99
15Nitrous oxide-15N2
15
99
16Formamide-15N
16
99
17Urea-15N2
17
99
18Amino-2-methyl-propanoic acid-15N salt
18
98
192-Amino-2-methyl -butanoic acid-15N salt
19
98
202-Amino-2-methyl-methyl propanoate-15N salt
20
98
212-Amino-2-methyl-methyl butanoate-15N salt
21
98
22Carbon monoxide-13C
22
80
23Carbon dioxide-13C
23
80
24Sodium bicarbonate-13C
24
80
252-Furoic acid (13C)
25
80
262-Cyanoacetic acid (1,2,3-13C3, 15N)
26
13C 98, 15N 98
27Ethyl cyanoacetate (1,2,3-13C3, 15N)
27
13C 98, 15N 98
282-cyanoacetamide (1,2,3-13C3, 15N)
28
13C 98, 15N 98
294-(2-Aminoethyl)benzene-1,2-diol
Dopamine:HCl (1-13C)
29
98
304-(2-Aminoethyl)benzene-1,2-diol
Dopamine:HCl (2-13C)
30
98
314-(2-Aminoethyl)benzene-1,2-diol
Dopamine:HCl (15N)
31
98
324-(2-Aminoethyl)benzene-1,2-diol
Dopamine:HCl (1-13C, 15N)
32
13C 98, 15N 98
334-(2-Aminoethyl)benzene-1,2-diol
Dopamine:HCl (2-13C, 15N)
33
13C 98, 15N 98
342-Aminomethyl-3-(3,4-dihydroxyphenyl)-propanamide (13C3, 15N)
34
13C 98, 15N 98
35(Z)-3-(3,4-bis(benzyloxy)phenyl)-2-cyano-2-propenamide (13C3, 15N)
35
13C 98, 15N 98
36Deuterated hydrochloric acid, solution
36
98
37Benzene-1,2-diol (Catechol)-D6
37
98
384-(2-Aminoethyl)benzene-1,2-diol (Dopamine)-D3
38
98
392-Amino-3-(3,4-dihydroxyphenyl) propanoic acid (L-Dopa)-D3
39
98

II. Analytical services

1. Food matrices

Authentication of food and beverage products based on isotopic fingerprints (13C, 2H, 18O):

  • determination of 18O/16O isotope ratios in water, wine, fruit juice, cider
  • determination of 13C/12C isotope ratios in ethanol in wine and alcoholic beverages; organic matter (dry matter) in milk, cheese, casein extracted from cheese, honey, meat

Determination of elemental concentrations in foodstuffs of animal/vegetable origin:

  • essential elements: Ca, Mg, K, Fe, Cu
  • toxic metals: Pd, Cd, As, Hg

Determination of organochlorine pesticide residues in food matrices: fruit, vegetables, milk and milk products
Assessment of fatty acid content and distribution in vegetable oils and foodstuffs
Characterisation of alcoholic beverages in terms of methanol and higher alcohols
Determination of isotope ratios (D/H)i in ethanol extracted from wine and spirits by measuring deuterium at natural abundance using NMR spectroscopy
 Metabolic fingerprinting by 1H-NMR spectroscopy of wines and spirits

2. Environmental matrices

 Qualitative and quantitative analysis of organic compounds by measuring different nuclei (1H, 2H, 13C, 15N, 19F, 31P) in liquid samples by NMR spectroscopy based on 1D and 2D experiments (COSY, ROESY, DOSY, HSQC, HMBC)
 Determination of the isotopic fingerprint of 2H and 18O in water samples (precipitation, mineral waters)
 Determination of the isotopic fingerprint of 13C and 14N in environmental matrices (soil, sediments, carbonates, loess)
Determinations of metals in environmental matrices
Determination of organochlorine pesticides in environmental matrices (soil, water, feed)
 Determination of petroleum products in soil

3. Health

 Drug identification based on carbon (13C/12C) and nitrogen (15N/14N) isotopic fingerprints
Determinations of metal concentration in drugs
Testing of food contact packaging and ceramic materials
Determinations of macro/micro minerals and toxic metals in food supplements
Intermolecular bioligand-macromolecule interactions investigated by spectroscopy, relaxometry and NMR scatterometry on liquid samples
Improving solubility and bioavailability of synthetic and natural bioactive substances by molecular encapsulation
 Studies on the binding of drugs to plasma proteins – used as molecular carriers

4. Cosmetic products

Quality assessment of cosmetic products in terms of toxic metal content
Determination of volatile organic compounds in essential oils (lavender, peppermint, and fir) and by-products from the distillation
 Determination of active substances in raw materials and disinfectants

III. Transfer of know-how for the separation of light stable isotopes

Scientific and technological expertise in the field of isotope separation: theoretical design of separation plants, testing of fillers, process automation